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From gefitinib to AZD3759. (a) Representative PET images of [18F]gefitinib in wild-type and Abcb1a/1b;Abcg2−/− mice; (b) Comparative quantitative results of brain uptake in wild-type, Abcb1a/1b−/−, Abcg2−/− and Abcb1a/1b;Abcg2−/− mice (*** p < 0.0001, summed 30–60 min post i.v. [18F]gefitinib injection) (Images in (a,b) adapted from [64] with permission from Elsevier); (c) Chemical structure of [11C]AZD3759.
