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(a) Radiosynthesis of [18F]afatinib and chemical structures of the irreversible covalent adducts upon interaction at the ATP binding sites of the ErBb protein family; (b) Comparative coronal PET images of [18F]afatinib in lung cancer-bearing mice with different EGFR mutation status. Red arrows indicate reference tissue. (This research was originally published in EJNMMI Research, [74]).
