Figure 8.

VEGFRs targeted radiotracers. (a) Chemical structures of radiolabeled inhibitors primarily targeting VEGFRs: [¹¹C]vandetanib, [¹¹C]chloro-vandetanib and R-[¹¹C]PAQ; (b) Chemical structures of vandetanib-derivatized ⁶⁴Cu-labeled monomeric ([⁶⁴Cu]23) and dimeric ([⁶⁴Cu]24) radiolabeled inhibitors; (c) Coronal PET/CT images of inhibitors [⁶⁴Cu]23 and [⁶⁴Cu]24 in U-87 tumor bearing mice and (d) corresponding quantitative analysis. ** p < 0.0001 (this research was originally published in [111] © the Society of Nuclear Medicine and Molecular Imaging, Inc.).