Figure 1.

Inhibition of VSMC proliferation by gentisin (1), determined by the resazurin conversion method. Cells were treated with the indicated concentrations of 1 for 48 h. (A) represents the data obtained from VSMC treated or untreated with PDGF, as well as the inhibitory effect of 30 µM 1 on PDGF-induced VSMC proliferation; (B) depicts the results obtained from dose response studies (investigated concentrations: 1, 3, 10, and 30 µM) used to determine the IC₅₀ of 1. Values are presented as means ± SD, relative to the PDGF stimulated solvent vehicle control (0.1% DMSO) (n = 3). *** p < 0.001, n.s. not significant (ANOVA/Bonferroni).