Figure 1.

Schematic showing multiple regulatory networks of aberrant expression of miR-223 in regulating bone metabolism. MiR-223(shown as red) can regulate differentiation of osteoclasts and osteoblasts by repressing transcriptional factors, such as NFIA, IKKα and FGFR2 (shown as blue). Solid arrows indicate the promotion of cellular processes. Dotted lines indicate the mechanism has not been fully elucidated. Red short arrows indicate the regulation of overexpression miR-223, and black short arrows indicate the regulation of knockdown expression of miR-223.