Table 4.

Examples of current clinical trials targeting PHDs.

Drug	Patient Population (Clinical Trial Phase)	Purpose of Study	Clinical Trials. Gov. Number (Status)
FG-4592	Subjects with anemia associated with chronic kidney disease without dialysis (phase III)	Evaluate the efficacy for treatment of anemia correction and hemoglobin correction as well as their maintenance	NCT01750190 (recruiting)
AKB-6548	Subjects with end stage renal disease undergoing chronic hemodialysis (phase II)	Evaluate the hemoglobin response (efficacy), safety, and tolerability	NCT02260193 (activated, but not recruiting)
GSK-1278863	Hemodialysis dependent subjects with anemia associated with chronic kidney diseases, chronically hyporesponsive to recombinant human EPO (phase II)	Evaluate the safety and efficacy after switching from recombinant human EPO	NCT02075463 (recruiting)
BAY-85-3934	Subjects with anemia associated with chronic kidney disease on dialysis, in USA and Japan (phase II)	Evaluate the efficacy and safety of oral BAY-85-3934 and active comparator in the long term treatment	NCT02064426 (recruiting)