Table 5.

In Vitro anti-HIV data for analogs of compound 41 [56].

Compound	Aryl Ring A			Aryl Ring B			EC50 (nM) a,b
	o	m	p	o	m	p
41	H	H	H	H	H	H	2100
42	F	H	H	H	H	H	900
43	H	H	F	H	H	H	1000
44	F	H	F	H	H	H	600
45	F	H	H	F	H	H	700
46	H	H	OMe	H	H	H	1800
47	H	H	F	H	H	F	800
48	H	H	Me	H	H	F	1600
49	H	Cl	F	H	H	H	800
50	H	H	OMe	H	H	OMe	>5000
51	F	H	F	F	H	F	300
52	H	F	H	H	H	H	2000
53	H	Cl	H	H	Cl	H	1100
54	H	Cl	F	H	Cl	H	1200
55	F	H	H	H	H	F	700
56	H	Cl	F	H	Cl	F	2400
57	H	H	Me	H	Cl	F	>5000
58	H	H	Me	H	Cl	H	2500
59	H	H	Me	F	H	H	700
60	H	H	F	H	Cl	F	>5000
61	F	Cl	F	H	H	H	600
62	H	H	F	H	Cl	H	1400
63	2,6-diF	H	H	H	H	F	1400
64	H	H	F	F	H	H	800
65	F	Cl	H	F	Cl	H	2400
66	H	H	Cl	H	Cl	H	2500
67	H	Cl	H	H	Cl	H	1400
68	F	Cl	H	H	Me	H	1400
69	F	H	F	F	H	H	600
70	H	Me	H	H	Cl	F	2200
71	F	Cl	H	H	H	H	700
72	F	5-Cl	H	H	H	H	900
73	F	Cl	H	H	Cl	H	1400
74	F	H	F	H	Cl	F	1400
75	H	Cl	H	H	H	F	1200
76	H	Cl	H	F	H	H	700
77	2,6-di-F	H	H	H	Cl	F	5100
78	2,6-di-F	H	H	H	H	H	1500
79	H	H	H	F	H	F	800
80	F	H	H	H	Cl	F	2200
81	H	F	H	F	H	H	1900
82	F	H	H	H	Cl	H	1900
83	F	F	H	H	H	H	900
82	H	Me	H	F	H	H	900
85	F	F	H	H	H	F	700
86	H	H	CN	F	H	H	1100
87	F	F	H	F	H	H	800
88	H	F	H	H	H	F	1000
89	F	H	F	Cl	H	H	800
90	H	Cl	H	F	Cl	H	1500
91	H	H	F	F	H	F	600
92	H	Me	H	F	H	F	700
93	H	H	H	H	COOH	H	>5000
94	H	H	H	Me	H	F	1300
95	H	H	F	Me	H	F	1000
96	F	H	H	F	H	F	500
97	F	H	H	Me	H	F	1300
98	H	Cl	F	F	H	H	790
99	F	H	F	H	H	F	420
100	F	Cl	H	F	H	H	500

^a EC₅₀ values are the average of three determinations. Standard deviations for the EC₅₀ are within 31% of the average. ^b EC₅₀ = concentration for 50% inhibition of the replication of HIV-1.