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IC50 data for inhibition of key cytochrome P450 isozymes for compound 96 [56].
| CYP450 Isozyme | Substrate (Stock Solution) | Conc. (µM ) | Protein (mg/mL) | Incubation (min) | IC50 Data (µM) * |
|---|---|---|---|---|---|
| CYP3A4 | Testosterone (50 mM ) | 100 | 0.3 | 30 | >200 µM |
| CYP3A4 | Triazolam (50 mM) | 200 | 0.4 | 30 | >200 µM |
| CYP2D6 | Dextromethorphan (50 mM) | 200 | 2.0 | 60 | >200 µM |
| CYP2C8 | Amodiaquine (5 mM) | 200 | 0.4 | 30 | >65 µM |
* IC50 is the concentration for 50% inhibition of the specified CYP isozyme from kinetic data.
