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. 2015 Sep 14;20(9):16741–16756. doi: 10.3390/molecules200916741

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© 2015 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Nematicidal activity of mimosinol and its derivatives (1a–1c), deuterated mimosinol (d-mimosinol) and its derivatives (2a–2c) against Caenorhabditis elegans. Dead and active nematodes were evaluated after 48 h treatment. Nematode mortality rate was calculated as a percentage relative to that recorded in the control group. Values are means of two independent experiments ± SE. The IC₅₀ values of mimosinol (376.2 μM), 1a (31.8 μM), 1b (50.2 μM), and 1c (116.1 μM). The IC₅₀ values of d-mimosinol (390.0 μM), 2a (251.6 μM), 2b (186.7 μM), and 2c (218.1 μM).