Table 1.

The pharmacophore model validation results of each group.

Model	Specificity	Energy	N_Hits	Ha a	Ht b	Ht-Ha c	A% d	N e	CAI f
Model_A018	4.33	2.89	6	12	29	17	16.22%	1.66	0.27
Model_A014	3.97	3.57	6	58	154	96	78.38%	1.51	1.18
Model_A010	3.96	3.80	6	20	124	104	27.02%	0.65	0.17
Model_A009	3.97	3.97	6	57	141	84	77.02%	1.62	1.25
Model_A002	3.97	4.06	6	57	148	91	77.02%	1.54	1.19
Model_B014	3.81	1.76	5	11	13	2	14.87%	3.39	0.50
Model_B013	3.81	2.20	6	10	13	3	13.52%	3.08	0.42
Model_B008	3.81	1.01	6	14	31	17	18.92%	1.81	0.34
Model_B015	3.66	3.33	6	11	20	9	14.87%	2.20	0.33
Model_B006	3.81	2.01	4	14	48	34	18.92%	1.17	0.22
Model_C002	4.02	13.66	4	39	41	2	52.70%	3.81	2.00
Model_C001	4.02	19.73	4	39	42	3	52.70%	3.71	1.96
Model_C003	4.02	13.87	4	39	44	5	52.70%	3.55	1.87
Model_C004	4.02	12.78	4	39	45	6	52.70%	3.47	1.83
Model_C010	4.02	14.99	4	40	46	6	54.05%	3.48	1.88

^a Ha is the number of active hits using pharmacophores to search. ^b Ht is the number of hits using pharmacophores to search. ^c Ht-Ha represents the number of false positive hits using pharmacophores to search. ^d A% represents the ability to identify active compounds from the test database. ^e N represents the ability to identify active compounds from inactive compounds. ^f CAI is the Comprehensive Appraisal Index.