Figure 1.

An overview of cellular endocytic mechanisms. The various endocytic uptake mechanisms are presented according to their dependency on either clathrin or dynamin. Most internalized cargo ends up in a common compartment, the early endosome (EE). From EEs, the cargo can either be directly recycled to the plasma membrane or be sorted to the recycling endosome (RE) before returning to the cell surface. Cargo that is not recycled may move down the endo-lysosomal pathway via multivesicular bodies (MVB) for degradation in the lysosome (Lys). Clathrin dep: Clathrin dependent. MP: macropinosome.