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. 2015 Dec 17;20(12):22578–22620. doi: 10.3390/molecules201219864

Figure 4.

Figure 4

The effect of polyphenols on apoptotic signaling pathways. Extrinsic (1) and intrinsic (2) apoptosis pathways are shown in the figure. The proteins with pro-apoptotic activity (caspases, Bax, Bak, Bid, Bad, IkB) are colored in blue, while the proteins with anti-apoptotic action (Bcl-2, Bcl-XL, PI3K, Akt, IKK, NF-kB) in red. EGCG, resveratrol, genistein and curcumin can inhibit anti-apoptotic proteins (Bcl-2) and stimulate the pro-apoptotic ones (Bax, Bak); caspases are stimulated by EGCG, quercetin and apigenin; the anti-apoptotic activity of NF-kB can be inhibited by apigenin [115,116,117,118,119,120,121]. Blue and red lines indicate stimulation and inhibition, respectively, of the process (for the sake of simplicity only the major proteins of the apoptosis pathways are shown).