Table 1.
Polysaccharide-based carriers for the bioavailability enhancement of poorly soluble drugs.
| Supramolecular Forces | Used Polysaccharides | Architecture Types | Drugs | References | |
|---|---|---|---|---|---|
| Non-covalent bond | Hydrogen bond | Hydrolyzed xyloglucan | Hydrogel | Ondansetron Indomethacin Mytomycin C | [133,134,135,136] |
| Hydroxypropyl Methylcellulose | Hydrogel | Indomethacin | [137] | ||
| Metal coordination | Alginate-calcium ion | Nanoparticle | Rifampicin, Doxorubicin | [138,139] | |
| N-succinyl chitosan-alginate | Hydrogel | Nifedipine | [140] | ||
| Alginate-calcium carbonate | Hydrogel | Ibuprofen | [141] | ||
| Ionic interaction | Chitosan-tripolyphosphate | Nanoparticle | Ciprofloxacin | [142] | |
| Chitosan-tripolyphosphate-hydroxypropylcyclodextrin | Nanoparticle | Furosemide, Triclosan | [143] | ||
| Chitosan-tripolyphosphate-dextran sulfate | Microsphere | Ibuprofen | [144] | ||
| Chitosan-dextran sulfate | Nanoparticle | Amphotericin B | [145] | ||
| Chitosan-glycyrrhetic acid | Nanoparticle | Glycyrrhetic acid | [146] | ||
| Chitosan-β-glycerophosphate | Hydrogel | Paclitaxel | [147] | ||
| Carrageenan Dextran sulfate | Nanosphere | Ciprofloxacin | [148] | ||
| Hydrophobic interaction | Ceramide modified hyaluronic acid | Nanoparticle | Docetaxel, Doxorubicin | [149,150] | |
| Deoxycholic acid modified hyaluronic acid | Nanoparticle | Paclitaxel | [151] | ||
| Histidine modified hyaluronic acid | Nanoparticle | Doxorubicin | [152] | ||
| Pullulan acetate | Nanoparticle | Silymarin | [153] | ||
| Cholesterol modified chitosan | Nanoparticle | Epirubicin | [154] | ||
| Deoxycholic acid-modified chitosan | Nanoparticle | Adriamycin, Doxorubicin | [155,156] | ||
| 5β-cholanic acid modified chitosan | Nanoparticle | Paclitaxel, Camptothecin | [157,158] | ||
| Stearic acid-g-chitosan | Nanosphere | Doxorubicin | [159,160] | ||
| N-acetyl histidine-conjugated glycol chitosan | Nanoparticle | Paclitaxel | [161] | ||
| Cholic acid modified dextran | Nanosphere | Indomethacin | [162] | ||
| CD polymer-dextran polymer | Nanogel | Benzophenone, Tamoxifen | [163] | ||
| Acetylated chondroitin sulfate | Nanogel | Doxorubicin | [164] | ||
| Covalent bond | Cross-linker or Copolymer | Chitosan (glutaraldehyde, sulphuric acid) | Microsphere | Diclofenac, Docetaxol Clozapine | [165,166,167] |
| Polyacrylamide-g-chitosan copolymer | Microsphere | Nifedipine | [168] | ||
| Chitosan-Pluronic copolymer | Nanoparticle | Indometacin, Doxorubicin | [169,170] | ||
| Pullulan-g-poly(l-lactide) copolymers | Hydrogel | Doxorubicin | [171] | ||
| Poly(dl-lactide-co-glycolide)-grafted pullulan | Nanosphere | Adriamycin | [172] | ||
| Cellulose-graft-poly(l-lactide) copolymers | Nanosphere | Paclitaxel | [173] | ||
| Dextran-b-poly(DL-lactide-coglycolide) copolymer | Nanosphere | Doxorubicin, Amphotericin B | [174,175] | ||
| Poly[lactic-co-(glycolic acid)]-grafted hyaluronic acid copolymer | Nanoparticle | Doxorubicin | [176] | ||
| Dextran-b-poly(ε-caprolactone) | Nanoparticle | Doxorubicin | [177] | ||
| Chondroitin sulfate-Pluronic copolymer | Nanoparticle | Doxorubicin | [178] | ||
| Starch (epichlorohydrin) | Microsphere | Ampicillin | [179] | ||
| Hyaluronic acid (1,3-diaminopropane) | Hydrogel | Ibuprofen | [180] | ||