Fig. 1.

BCP-ALL subtype-specific lncRNA expression signatures on discovery and validation cohorts. a PCA plot constructed from expression FPKM values of lncRNAs from 82 BCP-ALL samples obtained from RNA-seq. Each point represents a BCP-ALL sample. DUX4, Ph-like, NH-HeH, LH subtype, and others are represented by orange, rose, blue, green, and gray, respectively. b Heatmap illustrates unsupervised hierarchical clustering on 1235 DE subtype-specific lncRNAs (absolute fold change ≥ ± 1.5, P value ≤ 0.01) based on z-score transformed LIMMA normalized expression values. The subtype-specific lncRNAs from DUX4, Ph-like, and NH-HeH subytpes displayed in the plot. c Unsupervised hierarchical clustering of DE subtype-specific 1235 lncRNAs on the validation cohort (n = 47) with z-score transformed FPKM values. The heatmap represents three distinctive clusters of DUX4, Ph-like, and NH-HeH subtypes