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. 2019 Jan 14;12:8. doi: 10.1186/s13045-018-0692-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Relapse-specific DE lncRNAs from BCP-ALL subtypes. a–c Heatmap depicting the hierarchical clustering on relapse-specific DE lncRNA signature on z-score transformed LIMMA normalized expression values from DUX4, Ph-like, and NH-HeH subtypes. Each heatmap shows the up- and downregulated lncRNAs specific to ID and REL samples. d Molecular pathway analysis with the number of genes involved in each pathway from the enrichment analysis of the nearby (< 100 kb proximity) cis protein-coding genes correlated (Pearson correlation > 0.55 and P value ≤ 0.05) with relapse-specific DE lncRNAs in the DUX4 subtype. The legend box indicates the number of ID and REL samples within each group. Abbr.: CAMs; cell adhesion molecules