Fig. 5.

The epigenetically altered promoter methylated lncRNAs and their expression. a The promoter methylated lncRNAs with significant negative correlation with DE expression profile from the DUX4 subtypes. b, c Two representative examples of hypo-methylated lncRNAs with increased expression profile from DUX4 subtype. lncRNAs, RP11-138M12.1 (Pearson correlation coefficient = − 0.69, two-tailed P value = 5.21E−13), RP11-624MB.1 (Pearson correlation coefficient = −  0.50, P value = 1.36E−06) are examples with hypo-methylation and upregulated expression pattern with significant inverse correlation between DNA methylation and expression levels. d The promoter methylated lncRNAs with significant negative correlation with DE expression profile from the Ph-like subtypes. e A representative example of the promoter hyper-methylated lncRNA, RP11-138M12.1 (Pearson correlation coefficient = − 0.69, two-tailed P value = 5.21E−13) with downregulated expression pattern, and with inverse correlation within the Ph-like subtype