Table 2.
Summary of subgroup analysis
| Categories | Number of studies | Number of patients | Model | HR (95% CI) | I2 (%) | P h | Z | P |
|---|---|---|---|---|---|---|---|---|
| Study region | ||||||||
| Asian | 4 | 1016 | Fixed | 3.12 (0.54–5.20) | 31 | 0.23 | 4.85 | < 0.001 |
| Non-Asian | 5 | 1593 | Random | 3.03 (1.96–4.69) | 51 | 0.09 | 4.98 | < 0.001 |
| Sample size | ||||||||
| < 200 | 4 | 415 | Fixed | 1.84 (1.25–2.71) | 0 | 0.78 | 3.07 | 0.002 |
| ≥ 200 | 5 | 2194 | Fixed | 4.04 (2.98–5.50) | 0 | 0.8 | 8.92 | < 0.001 |
| FIGO stage | ||||||||
| I–IV | 8 | 2541 | Fixed | 2.98 (2.33–3.82) | 44 | 0.08 | 8.66 | < 0.001 |
| III–IV | 1 | 68 | Fixed | 3.05 (1.06–8.80) | NA | NA | 2.06 | 0.04 |
| Cut-off value (×109/L) | ||||||||
| 350 | 1 | 108 | Fixed | 1.37 (0.30–6.17) | NA | NA | 0.41 | 0.68 |
| 400 | 8 | 2501 | Fixed | 3.05 (2.39–3.89) | 39 | 0.12 | 8.95 | < 0.001 |
| Analysis method | ||||||||
| Multivariate | 5 | 1053 | Fixed | 2.47 (1.78–4.42) | 43 | 0.13 | 5.44 | < 0.001 |
| Univariate | 4 | 1556 | Fixed | 3.76 (2.63–5.37) | 0 | 0.46 | 7.25 | < 0.001 |
Random-effects model was used when P-value for heterogeneity test < 0.1; otherwise, fixed-effects model was used
Abbreviations: FIGO International Federation of Gynecology and Obstetrics, HR hazard ratio, CI confidence interval, Ph, P-value for heterogeneity based on Q test, P P-value for statistical significance based on Z test, NA Not applicable