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. 2019 Jan 14;19:66. doi: 10.1186/s12885-018-5257-x

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Estimated TGR₀ and TGR_Tx–Tx. *Pre-treatment TGR (TGR₀) is calculated from the second imaging test during the screening period (performed 12–24 weeks after the first screening period scan). LS means and P-values are derived from a mixed model with repeated measures. CI, confidence interval; LS, least squares; TGR, tumor growth rate; TGR₀, pre-treatment TGR, TGR_Tx–Tx, TGR between consecutive study visits during treatment