Table 1.
Prevalence of P. falciparum infection (PCR) according to miRNA-146 genotype in pregnant women attending ANC
| SNP rs2910164 | Positive cases | Univariate analysisa | Multivariate analysisb | ||
|---|---|---|---|---|---|
| % (Fraction) | OR (95% CI) | P | aOR (95% CI) | P | |
| All | 63.3 (322/509) | ||||
| Wild type | 55.5 (91/164) | 1 | 1 | ||
| Heterozygote | 64.9 (159/245) | 1.5 (1.0–2.3) | 0.063 | 1.4 (0.9–2.1) | 0.12 |
| Homozygote | 72.0 (72/100) | 2.1 (1.2–3.7) | 0.0089 | 2.3 (1.3–4.0) | 0.0053 |
| Het. or Hom. | 67.0 (231/345) | 1.6 (1.1–2.4) | 0.014 | 1.6 (1.1–2.4) | 0.023 |
| Primigravidae | 74.0 (94/127) | ||||
| Wild type | 60.0 (21/35) | 1 | |||
| Heterozygote | 75.4 (46/61) | 2.0 (0.8–5.5) | 0.17 | 1.8 (0.7–4.7) | 0.20 |
| Homozygote | 87.1 (27/31) | 4.4 (1.2–21.0) | 0.025 | 5.8 (1.6–26.0) | 0.012 |
| Het. or Hom. | 79.3 (73/92) | 2.5 (1.0–6.4) | 0.040 | 2.5 (1.0–6.2) | 0.040 |
| Multigravidae | 59.7 (288/382) | ||||
| Wild type | 54.3 (70/129) | 1 | 1 | ||
| Heterozygote | 61.4 (113/184) | 1.3 (0.8–2.2) | 0.24 | 1.3 (0.8–2.1) | 0.29 |
| Homozygote | 65.2 (45/69) | 1.6 (0.8–3.0) | 0.17 | 1.8 (0.9–3.4) | 0.082 |
| Het. or Hom. | 62.5 (158/253) | 1.4 (0.9–2.2) | 0.12 | 1.4 (0.9–2.2) | 0.14 |
Allele frequencies of SNP rs2910164 G > C were 0.47 (303/644) in infected and 0.38 (142/374) in non-infected women (P = 0.005)
OR odds ratio, aOR adjusted odds ratio
aFisher’s exact test for independence, compared to reference (wild type)
bLogistic regression model, including co-predictors age, PYR in urine or plasma and number of antenatal care visits. Effect of genotype on outcome variable was compared to reference (wild type)