Table 2.
Plasmodium falciparum (PCR) infection according to miRNA-146 genotype in placental blood of delivering primiparae
| SNP rs2910164 | Positive cases | Univariate analysisa | Multivariate analysisb | ||
|---|---|---|---|---|---|
| % (Fraction) | OR (95% CI) | P | aOR (95% CI) | P | |
| Primiparae | 64.9 (192/296) | ||||
| Wild type | 60.4 (55/91) | 1 | 1 | ||
| Heterozygote | 60.8 (87/143) | 1.0 (0.6–1.8) | 1.0 | 1.4 (0.7–2.9) | 0.38 |
| Homozygote | 80.6 (50/62) | 2.7 (1.2–6.4) | 0.013 | 5.9 (2.1–18.0) | 0.0011 |
| Het. or Hom. | 66.8 (137/205) | 1.3 (0.8–2.3) | 0.29 | 2.1 (1.0–4.2) | 0.038 |
Allele frequencies of SNP rs2910164 G > C were 0.49 (187/384) in infected (PCR) and 0.38 (80/208) in non-infected women (P = 0.02)
OR odds ratio, aOR adjusted odds ratio
aFisher’s exact test for independence, compared to reference (wild type)
bLogistic regression model, including co-predictors age, season, PYR in urine or plasma and number of antenatal care visits. Effect of genotype on outcome variable was compared to reference (wild type)