Table 3.
Past or present placental malaria (PCR, microscopy, haemozoin) according to miRNA-146 genotype in delivering primiparae
| SNP rs2910164 | Positive cases | Univariate analysisa | Multivariate analysisb | ||
|---|---|---|---|---|---|
| % (Fraction) | OR (95% CI) | P | aOR (95% CI) | P | |
| Primiparae | 67.9 (201/296) | ||||
| Wild type | 61.5 (56/91) | 1 | 1 | ||
| Heterozygote | 66.4 (95/143) | 1.2 (0.7–2.2) | 0.48 | 1.6 (0.8–3.5) | 0.21 |
| Homozygote | 80.6 (50/62) | 2.6 (1.2–6.1) | 0.013 | 5.9 (2.1–19.0) | 0.0013 |
| Het. or Hom. | 72.2 (145/205) | 1.5 (0.9–2.6) | 0.14 | 2.3 (1.1–4.7) | 0.020 |
OR odds ratio, aOR adjusted odds ratio
aFisher’s exact test for independence, compared to reference (wild type)
bLogistic regression model, including co-predictors age, season, PYR in urine or plasma and number of antenatal care visits. Effect of genotype on outcome variable was compared to reference (wild type)