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. 2019 Jan 14;23:12. doi: 10.1186/s13054-018-2303-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Randomised controlled trials (RCTs) of nutritional support in critically ill patients. The data are from the 142 published RCTs, as the information on the 28 RCTs registered on ClinicalTrials.gov was inadequate. Positive RCTs are those showing a statistically significant difference for the primary outcome; other RCTs are described as negative. a Shows the RCTs, with their size, according to type of primary outcomes used from 2000 to 2018. b Maps the studies according to population size and nature of the nutritional interventions