Table 3.

Classical prognostic factors and uPA and PAI-1 tumor tissue levels using standard reference cut-off values

Classical prognostic factors	uPA (ng/mg of protein)					PAI-1 (ng/mg of protein)
	Values		Categories			Values		Categories
	Mean (SD) Median (Range)	Wilcoxon rank sum	≤ 3	>  3	Pearson χ2 test	Mean (SD) Median (Range)	Wilcoxon rank sum	≤ 14	> 14	Pearson χ2 test
Tumor size
≤ 20 mm	3.9 (4.3) 2.5 (0.1–18.7)	nsa	21 (51.2%)	13 (32.5%)	nsb	17.7 (14.1) 12.5 (0.0–51.8)	nsa	18 (56.3%)	16 (32.7%)	nsb
20–30 mm	4.9 (3.8) 4.0 (0.5–15.5)		15 (36.6%)	22 (55.0%)		24.6 (22.9) 17 (7.5–140)		10 (31.3%)	27 (55.1%)
> 30 mm	4.3 (2.4) 5.1 (0.6–7.1)		4 (9.8%)	5 (12.5%)		24.6 (16.2) 24.5 (6.0–51.0)		3 (9.4%)	6 (12.2%)
Unknown	–		1 (2.4%)	–		–		1 (3.1%)	–
Tumor grade
Grade 1	4.1 (3.1) 5.2 (0.2–8.9)	ns	5 (12.2%)	6 (15.0%)	ns	20.4 (15.3) 18.6 (0.9–46.0)	ns	5 (15.6%)	6 (12.2%)	ns
Grade 2/3	4.4 (4.0) 3 (0.1–18.7)		36 (87.8%)	34 (85.0%)		21.6 (19.5) 16.0 (0.0–140)		27 (84.4%)	43 (87.8%)
Estrogen receptor
≥ 50%	4.1 (3.6) 2.9 (0.2–15.5)	ns	20 (48.8%)	18 (45.0%)	ns	21.9 (23.0) 15.3 (0.9–140)	ns	15 (46.9%)	23 (46.9%)	ns
< 50%	4.6 (5.2) 3.3 (0.1–18.7)		21 (51.2%)	22 (55.0%)		21.1 (14.6) 16.8 (0.0–56.8)		17 (53.1%)	26 (53.1%)
Ki67 index
< 15%	3.8 (4.0) 1.8 (0.2–13.3)	ns	14 (34.2%)	8 (20.0%)	0.039	17.0 (13.0) 13.8 (0.9–56.8)	0.038	11 (34.4%)	11 (22.5%)	ns
≥ 15%	4.8 (3.4) 5.1 (0.5–15.5)		10 (24.4%)	19 (47.5%)		27.5 (25.3) 20.0 (3.0–140)		7 (21.9%)	22 (44.9%)
Unknown	–	–	17 (41.5%)	13 (32.5%)		–		14 (43.8%)	16 (32.7%)
Total	81 (100%)	–	41 (100%)	40 (100%)	–	81 (100%)	–	32 (100%)	49 (100%)	–

^aKruskal Wallis Test; ^bFisher exact test; ns-not statistically significant