Fig. 1.

Structure of EcKPRS. The overall fold of the protein (a) is shown and the N- and C-termini are labeled (shown is chain A from 6ASV). α-helices are colored blue, β-strands are colored green, and loops are colored yellow. As seen in the structure and in the topology diagram (b), EcKPRS has two α/β/α-sandwich domains related by two-fold pseudo-symmetry. Both domains have a type I phosphoribosyltransferase fold