Table 2.
Characteristics and treatment outcomes of registered fresh cycles in assisted reproductive technology, Japan, 2016
| Variables | IVF‐ET | Split | ICSI | GIFT | Frozen oocyte | Others[Link] | Total | |
|---|---|---|---|---|---|---|---|---|
| Ejaculated sperm | TESE | |||||||
| No. of registered cycles | 89 857 | 24 754 | 133 709 | 2799 | 27 | 462 | 4220 | 255 828 |
| No. of egg retrieval | 87 656 | 24 545 | 131 873 | 2796 | 27 | 454 | 4048 | 251 399 |
| No. of fresh ET cycles | 25 649 | 6499 | 30 917 | 899 | 27 | ‐ | 506 | 64 497 |
| No. of freeze‐all cycles | 32 379 | 15 090 | 54 036 | 1261 | 0 | 395 | 1414 | 104 575 |
| No. of cycles with pregnancy | 5817 | 1555 | 5635 | 134 | 1 | ‐ | 85 | 13 227 |
| Pregnancy rate per ET (%) | 22.7 | 23.9 | 18.2 | 14.9 | 3.7 | ‐ | 16.8 | 20.5 |
| Pregnancy rate per egg retrieval (%) | 6.6 | 6.3 | 4.3 | 4.8 | 3.7 | ‐ | 2.1 | 5.3 |
| Pregnancy rate per egg retrieval excluding freeze‐all cycles(%) | 10.5 | 16.4 | 7.2 | 8.7 | 3.7 | ‐ | 3.2 | 9.0 |
| SET cycles | 21 199 | 5606 | 24 517 | 548 | 3 | ‐ | 365 | 52 238 |
| Pregnancy following SET cycles | 4825 | 1372 | 4484 | 94 | 0 | ‐ | 65 | 10 840 |
| Rate of SET cycles | 82.7% | 86.3% | 79.3% | 61.0% | 11.1% | ‐ | 72.1% | 81.0% |
| Pregnancy rate following SET cycles | 22.8% | 24.5% | 18.3% | 17.2% | 0.0% | ‐ | 17.8% | 20.8% |
| Miscarriages | 1508 | 357 | 1605 | 37 | 0 | ‐ | 24 | 3531 |
| Miscarriage rate per pregnancy | 25.9% | 23.0% | 28.5% | 27.6% | 0.0% | ‐ | 28.2% | 26.7% |
| Singleton pregnancies[Link] | 5518 | 1496 | 5318 | 121 | 1 | ‐ | 82 | 12 536 |
| Multiple pregnancies[Link] | 181 | 31 | 170 | 3 | 0 | ‐ | 1 | 386 |
| Twin pregnancies[Link] | 180 | 31 | 168 | 3 | 0 | ‐ | 1 | 383 |
| Triplet pregnancies[Link] | 1 | 0 | 2 | 0 | 0 | ‐ | 0 | 3 |
| Quadruplet pregnancies[Link] | 0 | 0 | 0 | 0 | 0 | ‐ | 0 | 0 |
| Multiple pregnancy rate (%)[Link] | 3.2 | 2.0 | 3.1 | 2.4 | 0.0 | ‐ | 1.2 | 3.0 |
| Live births | 4078 | 1123 | 3806 | 93 | 1 | ‐ | 58 | 9159 |
| Live birth rate per ET (%) | 15.9 | 17.3 | 12.3 | 10.3 | 3.7 | ‐ | 11.5 | 14.2 |
| Total number of neonates | 4206 | 1155 | 3916 | 95 | 1 | ‐ | 59 | 9432 |
| Singleton live births | 3930 | 1090 | 3666 | 89 | 1 | ‐ | 57 | 8833 |
| Twin live births | 135 | 31 | 122 | 3 | 0 | ‐ | 1 | 292 |
| Triplet live births | 2 | 1 | 2 | 0 | 0 | ‐ | 0 | 5 |
| Quadruplet live births | 0 | 0 | 0 | 0 | 0 | ‐ | 0 | 0 |
| Pregnancy outcomes | ||||||||
| Ectopic pregnancies | 68 | 26 | 77 | 1 | 0 | ‐ | 2 | 174 |
| Intrauterine pregnancies coexisting with ectopic pregnancy | 1 | 0 | 1 | 0 | 0 | ‐ | 0 | 2 |
| Artificial abortions | 23 | 6 | 28 | 0 | 0 | ‐ | 1 | 58 |
| Stillbirths | 22 | 5 | 19 | 0 | 0 | ‐ | 0 | 46 |
| Fetal reductions | 0 | 0 | 1 | 0 | 0 | ‐ | 0 | 1 |
| Unknown cycles for pregnancy outcomes | 105 | 35 | 95 | 3 | 0 | ‐ | 0 | 238 |
ET, embryo transfer; GIFT, gamete intrafallopian transfer; ICSI, intracytoplasmic sperm injection; IVF‐ET, in vitro fertilization‐embryo transfer; SET, single embryo transfer; TESE, testicular sperm extraction.
Others include ZIFT.
Singleton, twin, triplet, and quadruplet pregnancies were defined according to the number of gestational sacs in utero.