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Appearance of the external auricle and micrographs (200× magnification) of hematoxylin and eosin-stained ear sections after the mice were treated with the various formulations for 10 days. Normal, mice treated without any formulations; Model, treated with IMQ only; HA, hyaluronic acid; HA-ES, curcumin-loaded HA-modified ethosomes; ES, curcumin-loaded ethosomes; PGS, curcumin 25% propylene glycol solution; IMQ, imiquimod ointment; CP, clobetasol propionate cream.
