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Distribution of injected cells in major organs. (A) Fluorescently labeled iPSCs in the hearts, livers, lungs, and kidneys of healthy (left panels) and lung-injured (right panels) mice 8 h after receiving bolus injections of 2.5×108 cells/kg body weight via tail vein. (B) PCR analysis of Tet-On and 18S (18S rRNA gene) DNA levels in the organs. The Tet-On gene was carried into iPSCs by lentiviruses used for the induction of iPSCs from mouse fibroblasts.
