Figure 4.

Intravenously administered iPSCs did not differentiate into unwanted long-lasting cells or survive as quiescent stem cells. (A) Heart, lung, kidney, and liver of immunodeficient mice were free of human STEM 121 180 days after intravenous iPSC injection (the first four panels on the upper left). In the meantime, many cells in kidneys that received an intra-kidney injection 3 days before harvesting were positive for STEM 121 (upper right corner panel). (B) Pluripotent marker SSEA-4 was absent in all tissues harvested 180 days after tail vein iPSC injection and kidneys harvested 3 days after receiving intra-kidney injections.