Figure 7.

Therapeutic efficacy of C7G6-IgM in ferrets. (A-B) Virus titers in nasal washes from ferrets (n = 4 per group) treated with 20 mg/kg C7G6-IgM or control IgM (C5G6-IgM) 1 day after intranasal infection with 1×10⁷ TCID₅₀ of MA-B/Florida/4/2006 (A) or MA-B/Brisbane/60/2008 (B). Nasal washes were collected on the indicated days and titrated by TCID₅₀ assay. (C-D) Changes in body temperatures of ferrets treated with 20 mg/kg C7G6-IgM or control IgM (C5G6-IgM) 1 day after intranasal infection with 1×10⁷ TCID₅₀ of MA-B/Florida/4/2006 (C) or MA-B/Brisbane/60/2008 (D). (E-F) Body weight change curves of ferrets treated with 20 mg/kg C7G6-IgM or control IgM (C5G6-IgM) 1 day after intranasal infection with 1×10⁷ TCID₅₀ of MA-B/Florida/4/2006 (E) or MA-B/Brisbane/60/2008 (F). This experiment was repeated three times; one representative dataset is shown. Body temperatures and body weight change are expressed as the percentage of baseline values. The black bars indicate mean values and error bars represent SE. Statistical analysis was performed by t-test. *P < 0.05, **P < 0.01 and ***P < 0.001 compared to the control IgM-treated group.