Table 2.
Frequency of potential C7G6-IgM, C3G10-IgM, C11B10 or C10H10-IgG interacting residues.
| Antibody | Residue | Frequency (%) | Total (%) |
|---|---|---|---|
| C7G6-IgM | G156 | 99.4 | 99.4 |
| N165 | 52.3 | 99.9 | |
| S165 | 30.2 | ||
| I165 | 17.1 | ||
| K165 | 0.3 | ||
| N180 | 81.5 | 100 | |
| Y180 | 18.5 | ||
| C3G10-IgM | K144 | 58.2 | 95.4 |
| N144 | 37.2 | ||
| N211 | 94.9 | 96.7 | |
| D211 | 1.8 | ||
| T213 | 90.1 | 90.1 | |
| C11B10 | N179 | 81.5 | 100 |
| Y179 | 18.5 | ||
| C10H10-IgG | E212 | 52.0 | 100 |
| K212 | 48.0 |
A multiple sequence alignment of 2000 full-length influenza B HA sequences from the NCBI database was used to assess the genetic diversity and to calculate the frequencies of potential C7G6-IgM, C3G10-IgM, C11B10 and C10H10-IgG interacting residues. All of the residues listed were found in the HA proteins of influenza B viruses, all of which can be neutralized by the indicated antibodies.