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. 2019 Jan 14;19:69. doi: 10.1186/s12885-019-5294-0

Fig. 3.

Fig. 3

Representative image of the microsatellite markers used for the loss of heterozygosity analysis. The two LOH positive cases are shown. The formula employed was: LOH index = (N1/N2)/(T1/T2), corresponding to peak areas of N1 = constitutive DNA allele 1; N2 = constitutive DNA allele 2; T1 = tumor DNA allele 1; and T2 = tumor DNA allele 2 [4]. The distance of each marker from the CDH1 locus is approximate