Table 4.
False positive rates (null scenarios) and true positive rates (alternative scenarios) for three LRTs when the evolutionary process includes DT nucleotide substitutions between codons, ω variability among sites, and MNRs
SNR ( = 1) | High MNR ( = 0.05) | ||||||||
---|---|---|---|---|---|---|---|---|---|
ω 0 | ω 1 | ω 2 | LRT-1 | LRT-2 | LRT-3 | LRT-1 | LRT-2 | LRT-3 | |
Null scenarios | False positives | ||||||||
3a | 0.05 | 1.0 | 1.0 | 0.55 | 0.02 | 0.03 | 0.0 | 0.06* | 0.10* |
Alternative scenarios | True positives | ||||||||
3b | 0.05 | 0.5 | 2.0 | 0.95 | 0.87 | 0.92 | 0.01 | 0.44 | 0.26 |
3c | 0.05 | 1.0 | 2.0 | 0.99 | 0.47 | 0.46 | 0.0 | 0.27 | 0.18 |
LRT-1 compares M1a to M2a (under-fit models). LRT-2 compares G1ax to G2ax (perfect-fit models). LRT-3 compares G1a13 to G2a13 (over-fit models). The asterisk symbol (*) indicates that the results are based on < 100 replicates due to convergence problems with some datasets when there was high MNRs. For LRT-2 case 3a is based on 99 replicates. LRT-3 case 3a is based on 91 replicates