Table 2.
Representative SNPs and association statistics from each of four different SNP clusters/regions that are genome-wide significant
| SNP/risk allele | Allele frequency | Position (BP, Hg19) |
Odds ratio (95% CI) |
P value | Conditional OR* P value |
Joint OR** P value |
|---|---|---|---|---|---|---|
| rs140068132-G | 0.0933 | 6:151954834 | 0.58 (0.50–0.66) | 4.4 × 10− 15 | 0.61 (0.53–0.71) 6.8 × 10− 12 | |
| rs851980-C | 0.255 | 6:152027955 | 1.28 (1.18–1.35) | 5.2 × 10−10 | 1.22 (1.12–1.32) 1.0 × 10− 6 | 1.19 (1.10–1.28) 3 × 10− 6 |
| rs3778609-T | 0.192 | 6:152133187 | 0.76 (0.69–0.83) | 6.0 × 10−9 | 0.84 (0.76–0.93) 6.5 × 10− 4 | 0.86 (0.78–0.95) 0.0035 |
*Conditional on rs140068132
**Joint model with rs140068132, rs851985, and rs3778609