Figure 3.

Imaging of ¹⁸F-FDG uptake in WT mice compared to young and aged Tg4–42 mice. (A–C) MRI images were matched with predefined brain regions; coronal, transverse and sagittal view. (D–F) ¹⁸F-FDG-PET images of a WT mouse in coronal, transverse and sagittal view. (G–I) ¹⁸F-FDG-PET images of a young Tg4–42 mouse in coronal, transverse and sagittal view. (J–L) ¹⁸F-FDG-PET images of an aged Tg4–42 mouse in coronal, transverse and sagittal view. ¹⁸F-FDG uptake was distinctly lower in aged Tg4–42 mice compared to WT mice. In young Tg4–42 mice ¹⁸F-FDG uptake did not show significant differences in whole brain uptake but was reduced in the hippocampus, forebrain, hypothalamus, amygdala and midbrain. A, Amygdala; Bs, Brain Stem; C, Cortex; Cb, Cerebellum; H, Hypothalamus; Hc, Hippocampus; Hg, Harderian glands; M, Midbrain; O, Olfactory Bulb; S, Septum/Basal Forebrain; St, Striatum; T, Thalamus.