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Quantification of 18FDG uptake in all brain areas. Aged Tg4–42 mice showed significantly lower SUVGlc in all brain regions compared to WT. Differences between WT and young Tg4–42 mice were observed in the hippocampus, forebrain, hypothalamus, amygdala and midbrain. Aged Tg4–42 mice had lower SUVGlc in all areas except of amygdala and forebrain compared to young Tg4–42 mice. Unpaired t-test; ***p < 0.001, **p < 0.01, *p < 0.05 data presented as mean ± SEM.
