Figure 7.

Cognitive deficits in Tg4–42 mice. (A) Schematic representation of the novel object recognition task. (B) In the exploration phase of the novel object test, 7-month-old WT and Tg4–42 mice spent ~50% of the time with both objects. During the test trial, only WT mice showed a clear preference for the novel object, whereas Tg4–42 mice showed no preference for one of the objects. (C) Distance traveled did not alter between WT and Tg4–42 mice in the novel object task. (B) One-way analysis of variance (ANOVA) followed by Bonferroni multiple comparison; (C) unpaired t-test; **p < 0.01; data presented as mean ± SEM.