Table 1.

Identification of significant genomically altered genes from published TCGA data in 12 common cancer types.

Cancer type	Sample size	Significantly altered genes	Reference
Glioblastoma	206	TP53,ERBB2,NF1,PARK2,AKT3,FGFR2,IRS2,PTPRD,MLH1,MSH2,MSH6,PMS2,PIK3R1	doi:10.1038/nature07385
Lung squamous cell carcinoma	178	TP53,CDKN2A,PTEN,PIK3CA,MLL2,NOTCH1,RB1,HLA-A,NFE2L2,KEAP1	doi:10.1038/nature11404
Lung adenocarcinoma	230	TP53,NF1,RIT1,RBM10,ERBB2,MAP2K1,NRAS,HRAS,NKX2-1,TERT,MDM2,KRAS,EGFR,BRAF,PIK3CA,STK11,KEAP1,MET,CCNE1 CCND1, TERC,MECOM	doi:10.1038/nature13385
Colon rectal cancer	276	APC,TP53,KRAS,PIK3CA,FBXW7,SMAD4,TCF7L2,NRAS,CTNNB1 SMAD2,FAM123B,IGF2,NAV2,MYC,TGFBR2,BARF,MSH3,CASP8,CDC27,MAP7,PTEN,SOX9,ARID1A,FAM123B	doi:10.1038/nature11252
Breast cancer	510	PIK3CA,PTEN,AKT1,TP53,GATA3,CDH1,RB1,MLL3,MAP3K1,CDKN1B,TBX3,RUNX1,CBFB,AFF2,PIK3R1,PTPN22,PTPRD,NF1,SF3B1,CCND3	doi:10.1038/nature11412
Ovarian carcinoma	489	TP53,BRCA1,BRCA2,RB1,NF1,FAT3,CSMD3,GABRA6,CDK12,NOTCH,FOXM1,BRAF,PIK3CA,KRAS,NRAS,CCNE,MYC,ZMYND8,IRF2BP2,PAX8,TERT,ID4	doi:10.1038/nature10166
Endometrial carcinoma	373	PTEN,CTNNB1,PIK3CA,ARID1A,PPP2R1A,KRAS,MYC,ERBB2,CTNNB1,CCNE1,FGFR3,SOX17,TP53,PTEN,ARID5B,PIK3R1,FBXW7,POLE	doi:10.1038/nature12113
Urothelial bladder carcinoma	131	TP53,CDKN2A,FGFR3,PIK3CA,TSC1,RB1,HRAS,MLL2,CDKN1A,ERCC2,STAG2,RXRA,NFE2L2,ARID1A,KDM6A,EP300,FGFR3,PPARG E2F3, EGFR, CCND1,MDM2	doi:10.1038/nature12965
Clear cell renal cell carcinoma	446	VHL,PBRM1,BAP1,SETD2,HIF1A,PRKCI,MDS1,EVI1,MDM4,MYC,JAK2,CDKN2A,PTEN,NEGR1,QKI,CADM2,ARID1A,SMARCA4,PBAF	doi:10.1038/nature12222
Gastric adenocarcinoma	295	TP53,KRAS,ARID1A,PIK3CA,ERBB3,HLA-B,JAK2,PD-L1,PDCD1LG2,PTEN,SMAD4,CDKN2A,CDH1,RHOA	doi:10.1038/nature13480
Head and neck cancer	279	PIK3CA,TRAF3,E2F1,CDKN2A,HRAS,CASP8,NOTCH1,AJUBA,FAT1,NFE2L2,TP63,SOX2,EGFR,ERBB2,FGFR1	doi:10.1038/nature14129
Cervical cancer	228	APOBEC,SHKBP1,ERBB3,CASP8,HLA-A,TGFBR2,PD-L1,PDCD1LG2,BCAR4,KRAS,ARID1A,PTEN,PIK3CA,EP300,FBXW7,HLA-B,NFE2L2,MAPK1	doi:10.1038/nature21386