Figure 7. Insulin signal transduction at the level of TBC1D4 in the absence or presence of 100 nM insulin in myotubes from lean and severely obese subjects after 24 h of EPS + 3 h serum starvation (Estim).

A, TBC1D4 Thr⁶⁴² phosphorylation. B, TBC1D4 Ser⁵⁸⁸ phosphorylation. C, TBC1D4 Ser³⁴¹ phosphorylation. D, TBC1D4 Ser⁷⁰⁴ phosphorylation. E, TBC1D4 Ser³¹⁸ phosphorylation. Values are means ± SEM. n = 8 per group. ^* P < 0.05 for difference with EPS versus control condition. ^# P < 0.05 for difference between lean and obese.