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. Author manuscript; available in PMC: 2019 Jan 15.
Published in final edited form as: Methods Mol Biol. 2014;1176:107–114. doi: 10.1007/978-1-4939-0992-6_9

Fig. 1.

Fig. 1

Scheme for Fmoc-based solid-phase peptide synthesis with ruthenium-catalyzed olefin metathesis. Reactions are numbered by step within the protocol, where Subheading 3.2, step 2 represents the deprotection reaction, Subheading 3.2, step 4 the coupling reaction, and Subheading 3.3 the metathesis reaction. The chemical structure in Subheading 3.2, step 2 is that of piperidine, Subheading 3.2, step 4 the Fmoc-protected amino acid, and Subheading 3.3 the Grubbs catalyst. Gray ball represents rink amide MBHA resin