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. Author manuscript; available in PMC: 2019 Sep 21.
Published in final edited form as: ACS Chem Biol. 2018 Aug 31;13(9):2438–2448. doi: 10.1021/acschembio.7b00638

Figure 2.

Figure 2.

(A) X-ray structure of XMD11–50 bound to BRD4-BD1. (B) X-ray structure of XMD17–26 bound to BRD4-BD1. (C) Overlay of the two compounds highlighting the different angular configuration of the diazipinone ring system. The hydrophobic pocked composed by the side chains of Try81, Pro82 and Iso146 is highlighted in cyan.