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Working model that describes the possible participation of miR-643 in apoptosis of SW-480 cells driven by E. histolytica. Upregulation of miR-643 occurs after contact of SW-480 cells with parasites. Then miR-643 may target the XIAP 3′UTR inducing the downregulation of XIAP protein levels, which release the inhibition of caspase-3 and -9. In consequence the executioner caspase-3 triggers degradation of cellular proteins inducing the apoptosis of SW-480 cells.
