Table 1. Additional peptides synthesised in this study (all synthesised as CoA thioesters, yield indicating conversion of pure hydrazide to CoA conjugate, purity of all peptides > 90%).
Compound | Sequence | Yield [mg] | Yield [%] |
2 | d-Hpg/d-Tyr/l-Hpg/d-Hpg/d-Hpg/l-Phe | 0.78 mg | 12% |
3 | d-Hpg/d-Tyr/l-Hpg/d-Hpg/d-Hpg/l-4-cyano-Phe | 0.54 mg | 10% |
5 | d-Hpg/d-Cl-Tyr/l-Hpg/d-Hpg/d-Hpg/l-Cl-Tyr | 0.20 mg | 7% |
6 | d-Hpg/d-Cl-Tyr/l-Phe/d-Hpg/d-Hpg/l-Cl-Tyr | 1.2 mg | 8% |
D-1 | d-Hpg/d-Tyr/l-Hpg/d-Hpg/d-Hpg/d-Tyr | 0.73 mg | 9% |
D-4 | d-Hpg/d-Tyr/l-Phe/d-Hpg/d-Hpg/d-Tyr | 2.9 mg | 43% |
7 | d-Hpg/d-Tyr/l-Hpg/d-Hpg/d-Hpg | 1.0 mg | 9% |
8 | d-Hpg/d-Tyr/l-Phe/d-Hpg/d-Hpg | 3.7 mg | 34% |
9 | d-Hpg/d-Cl-Tyr/l-Phe/d-Hpg/d-Hpg | 3.3 mg | 60% |