Fig. 5. Mechanism of aggregation by platinum nanoparticles. Nanoparticle controls were dosed at log10 2.4 cm2 ml−1 as this was the surface area that induced maximal aggregation. The concentration of washed platelets was 2 × 108/ml. Platelets were preincubated with integrilin (9 μM), dasatinib (10 μM), PRT-060318 (10 μM) or vehicle (DMSO). Data is the mean + SEM of three experiments. Statistical analysis is based on a one-way anova and a Tukey test, where (**P < 0.01).
