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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Amyloid. 2018 Mar 23;25(2):93–100. doi: 10.1080/13506129.2018.1456425

Figure 5.

Figure 5.

Concentration-dependent inhibition of biotinyl-rVλ6Wil recruitment by AL-associated LC is significantly greater than for MM-derived LC proteins.(A) AL-associated LC, Cro (grey) yielded a greater concentration-dependent decrease (m, is the gradient) in recruitment inhibition, as compared to MM protein Gal (black). Mean ± SD, n= 6. Concentration-dependent gradient of inhibition of biotinyl-rVλ6Wil recruitment by a panel of 5 amyloid-associated LC (B; Cro, black triangle; Hig, gray square) or 4 MM LC proteins (C). Mean ± SD, n= 6. (D) Comparison of concentration-dependent inhibition of fibrillogenesis by MM protein Gal (grey) and transition protein Hig (black). Data were normalized to the lowest LC concentration. (E) The cohort of AL-associated LC (grey), including transition protein Hig (square), inhibited recruitment significantly more than MM-derived LC proteins (black). Mean ± SD, n = 6. (F) ROC analysis of the data presented in (E). A 100% sensitivity and 100% specificity was achieved at m = −5.45. An unpaired, two-tailed t-test was used to analyze the data in (D and E).