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Overview of the study design. ARIC, Atherosclerosis Risk in Communities; CARDIA, Coronary Artery Risk Development in Young Adults; CHS, Cardiovascular Health Study; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; FHS, Framingham Heart Study; GRS, genetic risk score; MR, Mendelian randomization; SNV, single nucleotide variant; SU, serum urate.
