Table 1. Base case values and distributions applied in probabilistic sensitivity analysis.

	Base case value	Probabilistic sensitivity analysis distribution	Base case source
Health outcomes
CHD free (QoL)	0.90	Not varied	[20,25]
Disutility due to non-fatal CHD event (QALY)	-0.147	-1 × Beta(52,304)	[20,26–28]
Probability of death in case of event	22%	Beta(48,173)	[29]
Expected time of CHD event	5.75 years	Not varied	[5]
Risk reduction if statin treatment	-27%	-1 × Beta(45,121)	[30]
Annual side effect of statin treatment (QoL)	-0.002	Not varied	[31,32]
Discount rate of health outcomes	3%	Not varied	[24]
Costs
Costs of obtaining traditional factors incl. blood panel, doctor and nurse visits (€)	173€	Not varied	[33]
Genetic testing (€)	200€	Unif(100,300)	Expert opinion
Annual statin costs (€/person)	53€	Not varied	[34,35]
Annual monitoring of a patient receiving statins (in primary prevention)	173€	Not varied	[33]
Annual secondary prevention	451€	Not varied	[36]
Non-fatal CHD event (undiscounted)	19,860€	Gamma(171,116)	National Discharge Register
Fatal CHD event (undiscounted)	2,417€	Gamma(171,14)	[35,36]
Willingness-to-pay threshold	50,000€		Assumption
Discount rate of costs	3%	Not varied	[24]

CHD, coronary heart disease; QoL, quality of life; QALY, quality-adjusted life-year.