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. 2019 Jan 15;14(1):e0210248. doi: 10.1371/journal.pone.0210248

Fig 2. Deletion of LRRK2 attenuates Mn-induced apoptosis and cell death in RAW 264.7 cells.

Fig 2

(A) LRRK2 WT or KO RAW 264.7 cells were treated with Mn (250 μM) for the designated times, followed by flow cytometry analysis to determine Mn-induced apoptosis. Both early and late apoptotic cells (Q2 and Q3) were measured. (B) At the end of Mn exposure, cell viability was determined by MTT assay. @@@, p < 0.001; ###, p < 0.001; ***, p < 0.001 compared to the control (one-way ANOVA followed by Tukey’s post hoc test; n = 3, for apoptosis assay; n = 6, for MTT assay). The data shown are representative of 3 independent experiments.