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. 2019 Jan 15;14(1):e0210248. doi: 10.1371/journal.pone.0210248

Fig 10. Inhibition of p38 and ERK attenuates Mn-induced oxidative stress and cell death.

Fig 10

(A,B) After pre-treatment with LRRK2 inhibitors GSK (1 μM) and MLi-2 (50 nM), p38 inhibitor SB 203580, or ERK inhibitor PD 98059 for 90 min, cells were exposed to Mn (250 μM) for the designated time periods, followed by ROS and MTT assays as described in the Methods section, (###, p < 0.001; **, p < 0.01; ***, p < 0.001 compared to the control (one-way ANOVA followed by Tukey’s post hoc test; n = 6). The data shown are representative of 3 independent experiments.