Table 1. Patients and serum characteristics.
| Significance (P) |
||
|---|---|---|
| Number of samples | 226 | |
| Gender | ||
| Male | 110 | |
| Female | 116 | |
| Age (years) | ||
| Mean±SD (years) | 22.94±12.66 | |
| 3–14 | 55 | |
| 14–45 | 150 | |
| 45–59 | 21 | |
| LTG dose (mg/day) | 158.50±52.38 | |
| LTG dose/weight (mg/kg/day) | 3.06±1.13 | |
| LTG serum concentration (μg/ml) | ||
| Mean±SD | 5.48±3.83 | |
| Male | 5.60±3.81 | 0.64 |
| Female | 5.36±3.85 | |
| 3–14 | 4.99±3.55 | 0.05 |
| 14–45 | 5.88±3.94 | |
| 45–59 | 3.92±3.32 | |
| Type of concomitant AEDs(number of samples) | ||
| Group A: LTG monotherapy | 71 | |
| Group B: LTG+AEDs with inducer CBZ as the only concomitant AED OXC as the only concomitant AED TPM as the only concomitant AED CBZ + TPM as the concomitant AEDs |
39 10 14 10 5 |
|
| Group C: LTG+VPA | 68 | |
| Group D: LTG+AEDs with non-inducer | 11 | |
| Group E: LTG+VPA+ AEDs with inducer | 15 | |
| Group F: LTG+VPA+AEDs with non-inducer | 22 |
Abbreviation:
AEDs: Antiepileptic drugs
LTG: Lamotrigine
CBZ: Carbamazepine
OXC: Oxcarbazepine
VPA: Valproic acid
TPM: Topiramate