Table 1. GDF-15 measured in plasma samples from 235 patients with endometrial cancer in relation to clinicopathological factors.
| Low, n (%) | High, n (%) | P-value* | |
|---|---|---|---|
| Age, y | <0.001 | ||
| <66 | 86 (84) | 16 (16) | |
| ≥66 | 71 (53) | 62 (47) | |
| FIGO | 0.003 | ||
| I/II | 140 (71) | 58 (29) | |
| III/IV | 17 (46) | 20 (54) | |
| Histologic type | 0.002 | ||
| Endometrioid | 126 (72) | 48 (28) | |
| Non-endometrioid | 31 (51) | 30 (49) | |
| Non-endometrioid types | 0.003 | ||
| Clear cell | 4 (40) | 6 (60) | |
| Serous | 20 (61) | 13 (39) | |
| Carcinosarcomas | 3 (25) | 9 (75) | |
| Undifferentiated | 4 (67) | 2 (33) | |
| Histologic grade** | 0.002 | ||
| Grade 1 | 76 (84) | 15 (16) | |
| Grade 2 | 27 (55) | 22 (45) | |
| Grade 3 | 18 (64) | 10 (36) | |
| Myometrial infiltration | 0.001 | ||
| <50% | 101 (75) | 33 (25) | |
| ≥50% | 55 (56) | 44 (44) |
*P-values are calculated by Chi-Square test or Fisher exact test.
**Endometrioid included only.
Low = 1. and 2. tertile
High = 3. tertile
FIGO: International Federation of Gynecology and Obstetrics